DOCK5 Antibody, FITC conjugated

Code CSB-PA875689LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DOCK5 Polyclonal antibody
Uniprot No.
Target Names
DOCK5
Alternative Names
DOCK5Dedicator of cytokinesis protein 5 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Dedicator of cytokinesis protein 5 protein (1-200AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen.
Gene References into Functions
  1. our work identifies DOCK5 as a key regulator of epithelial invasion and metastasis, and demonstrates that suppression of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of Rho and Rac GTPases. PMID: 27669437
  2. the potential role of DOCK5 in human obesity PMID: 22595969
  3. along with DOCK1, DOCK5 is an important mediator of CrkII/CrkL regulation of Caco-2 spreading and migration on collagen IV. PMID: 19004829
Subcellular Location
Cytoplasm. Cell membrane.
Protein Families
DOCK family
Database Links

HGNC: 23476

OMIM: 616904

KEGG: hsa:80005

STRING: 9606.ENSP00000276440

UniGene: Hs.195403

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